Hotel Regina is located on Avignon's main street, a 5-minute walk from the Palais des Papes. Rooms are decorated in warm colors and also include a flat-screen TV with satellite channels. Free Wi-Fi is available and some rooms have a balcony. The private bathroom has a bath or shower. Additional facilities at this hotel include a 24-hour front desk and an elevator that serves most rooms. The property is a 10-minute walk from Avignon Train Station. Simply furnished rooms feature high ceilings, flat-screen TVs and free Wi-Fi. Some rooms have air conditioning and balconies. Family rooms can accommodate 3 or 4 people.

The hotel has no restaurant.