The hotel is in the Torre (tower) and Colonial areas (featuring colonial styles from the 17th century). Built in 1942 and renovated in 2001, the hotel offers a total of 180 rooms. In addition, guests are welcomed in the lobby area with a reception desk manned around the clock, a hotel safe, a currency exchange desk and lift access. Conference facilities are also available along with car rental, a tobacco shop, Internet access (WLAN), medical assistance as well as room and laundry services. A playground, a garage and a car park are additionally on offer. Mérida Grill restaurant serves regional, national and international cuisine, La Terraza lobby bar offers various drinks, coffee varieties, pancakes, sweet dishes as well as live music and La Trova, Estudio de Sergio Esquival bar is a romantic local with Yucatan troubadour music.

Hotel Mision Merida Panamericana is located in the Historical Center of Merida City 3 blocks away from the Main Square and only one block away from Mejorada Park. 20 minutes from Manuel Crescencio Rejon International Airport and 25 minutes away from the main Yucatan port, Progreso

La Casa Antigua Restaurant offers fine Yucatan dining from 12:00 to 22:00 hrs daily, exclusively for lunch and dinner service. With indoor air conditioning areas and outdoor areas as well, is decorated in chic French design. Terraza , Coffee Shop offers a full buffet service from 7:00 to 11:30 hrs.