The hotel is a quiet enclave with spectacular views of the Atlantic Ocean, Biscayne Bay and downtown Miami. The curvilinear modernist building has 335 studios, 1 and 2-bedroom rooms and penthouses designed by one of the world's most inventive young talents: multiple award-winning Dutch designer Marcel Wanders. The Mondrian South Beach is pioneering revolutionary, world-class design in a growing neighbourhood for a new generation of style-conscious travellers. The hotel also features a rooftop lounge and offers extensive banquet and private event facilities which are available for outdoor and indoor meetings, luncheons and dinner parties. A parking fee of 42 USD per car per night applies for those arriving by car (rate subject to change). The hotel provides cheque cashing privileges, currency conversion and exchange services. Other facilities available to guests at this air-conditioned hotel include a lobby with a 24-hour reception service, hotel safe, restaurant and room service (fees apply).

Located directly on Biscayne Bay on the newly fashionable West Avenue and minutes away from the centre of South Beach, the hotel is within walking distance of nightlife, restaurants and shopping venues. Also close by is the Lincoln Road Mall, the central business district, museums and the Miami Beach Convention Center. Miami Beach Golf Club is a 6-minute drive from the hotel, as is Jungle Island. Nearby airports include Miami International Airport (16 km) and Fort Lauderdale/Hollywood International (45 km).

The hotel features on-site dining such as the bayside bar and grill. Breakfast is served each morning and lunch and dinner are available from set menus.